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Collaborators using OpenPolScope Instrumentation

Zvonimir Dogic, Brandeis University, Waltham, Massachusetts

The Dogic Group is interested in studying various structural and dynamical aspects of diverse biopolymer assemblages. In particular, we have recently demonstrated assembly of colloidal membranes, which consist of one-rod-length think liquid monolayer of colloidal rods. There are significant similarities as well as important differenced between colloidal monolayers and lipid bilayers. PolScope technology allows us to directly visualize the membrane structure. We are currently analyzing how various inclusions locally distort the structure of colloidal membranes and how these deformation lead to membrane mediated interactions.

Amy Gladfelter, Dartmouth College, Hanover, New Hampshire

The Gladfelter lab is interested in how cells are organized in time and space.  We study how cells manage time to create highly variable yet accurate cell division cycles.  We also look at how cells use the septin cytoskeleton to assemble functionally unique zones on the cell cortex.  For our work we combine live cell microscopy and computational approaches with genetic and biochemical analyses.

James R. LaFountain, University at Buffalo, Buffalo, New York

Live cell imaging offers a way to gain insight into dynamic features of important biological processes. Research in my lab uses this approach in combination with other micro-techniques, namely microinjection and laser microsurgery, to investigate poorly understood mechanisms behind segregation of chromosomes within the spindle during meiosis. Spermatocytes from crane flies (Nephrotoma suturalis) are an ideal model system for the work because they have few chromosomes and a large, clear spindle.

Gus Rosania, University of Michigan College of Pharmacy, Ann Arbor, Michigan

The Rosania Research Group studies the microscopic transport properties of small drug-like molecules inside cells.  As an overarching hypothesis, we propose that a drug's microscopic distribution within cellular organelles is a major determinant of drug efficacy and toxicity, as important as its macroscopic distribution in the organs of the body

Tomomi Tani and Maki Koike-Tani,  MBL, Woods Hole, Massachusetts

Tomomi Tani: How are molecular assemblies built in a spatially organized manner in response to temporal and spatial signals in the living cell? We are developing a new fluorescence microscope to reveal the three dimensional orientations of individual molecules while being assembled in 3D architectures in living cells, multi-cellular tissues and in whole living organisms.

Maki Koike-Tani: Taking advantage of label-free imaging, established at the MBL, I have started to develop new approaches to non-invasive imaging of neuronal activity by using polarized light microscopy.

Sara Abrahamsson, MBL and HHMI / The Rockefeller University, New York, New York

Multifocus microscopy (MFM) is an optical technique that simplifies 3D imaging of quickly moving samples by modifying a regular fluorescence microscope. Instead of the regular 2D image, it creates an instant 3D image of nine focal planes. I am spending the summer of 2013 as a Whitman Investigator at the MBL implementing an imaging system which combines the OpenPolScope with MFM. This imaging system is intended for 3D polarization imaging of living cells and tissues.

 

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